- Claude Bernard -
“The joy of discovery is certainly the liveliest that the mind of man can ever feel”
PUBLICATIONS
PATENTS
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桑自剛*、林政源 (2012) 利用屏蔽效應檢測多巴胺及其檢測試劑. ROC patent #I372183
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Sang TK* and Lin CY. (2013) Utilization of shield effect for dopamine detection and reagent development. US patent #8,426,220
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Chang HY, Sang TK*, Chiang AS. (2018) Untangling the Tauopathy for Alzheimer's disease and parkinsonism. J Biomed Sci. 25(1):54.
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Viswanathan MC, Blice-Baum AC, Sang TK*, Cammarato A. (2016) Cardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function. J Cardiovasc Dev Dis. 3(2). pii: 19.
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Liang CJ, Chang YC, Chang HC, Wang CK, Hung YC, Lin YE, Chan CC, Chen CH, Chang HY, Sang TK*. (2014) Derlin-1 Regulates Mutant VCP-Linked Pathogenesis and Endoplasmic Reticulum Stress-Induced Apoptosis. PLoS Genet 10(9):e1004675.
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Santhanam A., Peng WH, Yu YT, Sang TK*, Chen GC, Meng TC. (2014) Ecdysone -induced receptor tyrosine phosphatase PTP52F regulates Drosophila midgut histolysis by enhancement of autophagy and apoptosis. Mol. Cell. Biol. 34(9):1594-1606.
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Chan HT, Lee TR, Huang SH, Lee HY, Sang TK*, Chan HL and Lyu PC. (2012) Proteomic analysis of a drosophila IBMPFD model reveals potential pathogenic mechanisms. Mol. BioSystems. 8(6):1730-41.
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Wang CT, Chen YC, Wang YY, Huang MH, Yen TL, Li H, Liang CJ, Sang TK*, Ciou SC, Yuh CH, Wang CY, Brummel TJ, Wang HD. (2012) Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila. Aging Cell.11(1):93-103.
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Chatterjee S, Sang TK*, Lawless GM, Jackson GR.(2009) Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum Mol Genet. 18(1):164-77.
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Sang TK*, Chang HY, Lawless GM, Ratnaparkhi A, Mee L, Ackerson LC, Maidment NT, Krantz DE, Jackson GR.(2007) A Drosophila model of mutant human parkin- induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine. J Neurosci. 27(5):981-92.
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Karsten SL, Sang TK*, Gehman LT, Chatterjee S, Liu J, Lawless GM, Sengupta S, Berry RW, Pomakian J, Oh HS, Schulz C, Hui KS, Wiedau-Pazos M, Vinters HV, Binder LI, Geschwind DH, Jackson GR. (2006) A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau- induced neurodegeneration. Neuron. 51(5):549-60.
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Jackson, GR, Sang, TK* and Taylor, JP. (2006) Drosophila Models of Polyglutamine Disorders. Ed.: Wells, R., and Ashizawa, Genetic Instabilities and Neurological Diseases. pp. 587-594. San Diego: Elsevier.
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Sang TK*, Jackson GR. (2005) Drosophila models of neurodegenerative disease. NeuroRx. 2(3):438-46. Review.
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Mee L, Honkala H, Kopra O, Vesa J, Finnila S, Visapaa I, Sang TK*, Jackson GR, Salonen R, Kestila M, Peltonen L. (2005) Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1. Hum Mol Genet. 14(11):1475-88.
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Sang TK*, Li C, Liu W, Rodriguez A, Abrams JM, Zipursky SL, Jackson GR. (2005) Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. Hum Mol Genet. 14(3):357-72.
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Jackson GR, Wiedau-Pazos M, Sang TK*, Wagle N, Brown CA, Massachi S, Geschwind DH. (2002) Human wild-type tau interacts with wingless pathway components and pro duces neurofibrillary pathology in Drosophila. Neuron. 34(4):509-19.
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Sang TK*, Ready DF. (2002) Eyes closed, a Drosophila p47 homolog, is essential for photoreceptor morphogenesis. Development. 129(1):143-54.
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Chang, HY, Sang, TK, Jan, KY, and Chen, CT. (1995) The cellular DNA contents and cell volumes of batoids and their systematics. Copeia. 3: 571-576.
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Sang TK*, Chang HY, Chen CT, Hui CF. (1994) Population structure of the Japanese eel, Anguilla japonica. Mol Biol Evol. 11(2):250-60.